Critical Care Product

Teicoplanin – a critical care product

A critical care product Teicoplanin is available as Ticoviz from Vistica Life. Teicoplanin is a semisynthetic glycopeptides antibiotic. It works by inhibiting bacterial cell wall synthesis. The spectrum of activity of Teicoplanin is similar to vancomycin. This antibiotic is used in the prophylaxis and treatment of critical infections gram-positive bacteria. It also includes methicillin resistant bacteria.

Teicoplanin is marketed by Vistica Life Sciences  under the trade name of Ticoviz. Vistica offers a quality product for the treatment of critical cases. Vistica has a big range of critical care product.

Teicoplanin of Vistica is available in oral as well as injection forms. Its oral use has been demonstrated to be effective in the treatment of pseudomembranous colitis and Clostridium difficile-associated diarrhoea, when compared with the efficacy with vancomycin. The strength of Teicoplanin lies in its length of the hydrocarbon chain.

It belongs to the Micromonosporaceae family produced by rare actinobacterium actinoplances teichomyceticus.

Teicoplanin is an effective antimicrobial against Gram-positive bacteria including Staphylococci and Clostridium as it targets peptidoglycan synthesis . The following data for a few medically significant pathogens represents MIC susceptibility for the pathogens:

• Staphylococcus epidermidis: ≤0.06 μg/ml – 32 μg/ml
• Clostridium difficile: 0.06 μg/ml – 0.5 μg/ml
• Staphylococcus aureus: ≤0.06 μg/ml – ≥128 μg/ml

Chemistry of Teicoplanin – a critical care product:

Teicoplanin (Ticoviz that is marketed by Vistica Life Sciences) is actually a mixture of several compounds.

The structures of the teicoplanin core and the side-chains of teicoplanin compounds are shown below.

Teicoplanin (Ticoviz a critical care product of Vistica)  refers to a complex of a group of five structures. These structures have a common aglycone consisting of seven amino acids. These amino acids are bound by peptide and bonds to form a four-ring system. These five structures differ in identity of the fatty acyl side-chain attached to the sugar..

(for detailed study on the matter mentioned above please visit https://en.wikipedia.org/wiki/Teicoplanin . things have been quoted from this site. There may be interpretation mistakes )

Therapeutic indications of Teicoplanin is indicated in adults and in children for the treatment of the following infections:

• complicated skin and soft tissue infections,
• bone and joint infections,
• hospital acquired pneumonia,
• community acquired pneumonia,
• complicated urinary tract infections,
• infective endocarditis,
• peritonitis associated with continuous ambulatory peritoneal dialysis (CAPD),
• bacteraemia that occurs in association with any of the indications listed above.

Teicoplanin is also indicated as an alternative oral treatment for Clostridium difficile infection-associated diarrhoea and colitis.Teicoplanin should be used in combination with other antibacterial agents when considered appropriate.

Note: Consideration should be given to official guidance on the appropriate use of antibacterial agents.

Posology and method of administration

The dose and duration of treatment with teicoplanin should be adjusted according to the type and severity of infection and clinical response of the patient and the factors such as age and renal function.

During maintenance treatment, teicoplanin trough serum concentrations monitoring may be performed at least once a week to ensure that these concentrations are stable.

The duration of treatment with teicoplanin must be decided based on the clinical response. Treatment should not exceed 4 months.

Teicoplanin is suggested not to  be administered by intraventricular use.

Teicoplanin has been reported with some serious life threatening sensitivity reactions. It is suggested that if an allergic reaction occurs, the treatment should be discontinued immediately and all precautionary measures must be initiated immediately.

All precautions may be taken before administering Teicoplanin to the patient known to have hypersensitivity to vancomycin.

In rare cases, red man has been observed with Teicoplanin even at the first dose. Stopping or slowing the infusion may help in the cessation of these reactions.

Thrombocytopenia has been observed with teicoplanin . Therefore a  periodic haematological examinations are recommended during treatment.

The patients treated with teicoplanin have been reported with nephrotoxicity and renal failure. A full precaution must taken in the adjustment of the dosage.

The use of teicoplanin must be avoided during pregnancy. There is a potential risk of inner ear and renal damage to the foetus.

It has been observed that teicoplanin – a critical care product, can cause dizziness and headache. It can cause minor influence on the ability to drive and use machines. Patients on teicoplanin should avoid driving or using machines.

Teicoplanin is effective in Corona virus. As we know that a novel coronavirus came into existence from China causing pneumonia outbreaks.  Its spread started in the Wuhan region of China and then spread worldwide. It spread worldwide because of its probable high transmission efficiency. This coronavirus is responsible for respiratory infections including pneumonia, with an estimated mortality rate of approximately 2–2.5

Teicoplanin, a glycopeptide antibiotic which was used to treat bacterial infections, was found to be active in vitro against SARS-CoV.  This antibiotic, has  shown its efficacy against various viruses such as Ebola virus, influenza virus, flavivirus, hepatitis C virus and human immunodeficiency virus (HIV) as well as coronaviruses.

Based on the experience of teicoplanin use in the treatment of infectious diseases, it is herby encouraged further investigation of the antiviral effect of this molecule on SARS-CoV-2 and suggest teicoplanin as another potential alternative for the treatment of COVID-19.

Vistica Life Sciences offers Ticoviz – the brand for Teicoplanin.

ALL ABOVE INFORMATIONS ARE TAKEN ON LINE FROM THE LINKS MENTIONED. FOR CLARITY OF THE POINTS MENTIONED IN THIS, IT IS SUGGESTED TO VISIT THE SITES ON LINE.