Critical Care PCD Franchise Company
Critical Care PCD Franchise Company – Drug Tigecycline
Vistica Life, a critical care pcd franchise company, introduces Tigecycline. Tigecycline belongs to the glycylcycline class of antibiotics. It has a broad spectrum activity including against drug resistant gram positive organisms. In the treatment of complicated skin or intra-abdominal infections, tigecycline has shown its proven efficacy in randomized trails.
Starting with a 100mg loading dose, tigecycline should be given 50mg intravenously every 12 hours. The common adverse effects associated with tigecycline therapy are nausea, vomiting and diarrhea. These side effects may cause in the discontinuation of therapy. Blistering or peeling skin, Rash, hives, tingling or swelling of the face, neck, throat, tongue, lips, or eyes, difficulty breathing or swallowing, itching, ongoing pain that begins in the stomach area but may spread to the back, sore throat, fever, chills, and other signs of new or worsening infection
Tetracycline group is a broad spectrum antibiotic that came into existence in mid 1900. But the use of the tetracycline group in the recent years has been very limited due to its widespread resistance to microorganisms. Therefore, glycyclcyclines came into existence and was developed to overcome tetracycline resistance. Tigecycline is the first drug in glycylcycline.
Tigecycline by blocking the entry of transfer RNA, binds to the bacterial 30S ribosome and prevents protein synthesis. Tigecycline’s affinity for the ribosomal has been increased when compared to tetracycline or minocycline. This further expands spectrum of activity and chances of resistance development is decreased.
Tigecycline is highly protein bound and is 100% bioavailable as it is administered intravenously. It offers higher concentration in gallbladder, lung and colon while its concentration in bone and synovial fluid are lower. It has an elimination half-life of approximately 36 hours and is mainly eliminated as unchanged drug.
Tigecycline acts as a bacteriostatic agent against Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, and Staphylococcus aureus. While it acts both Bacteriostatic and bacteriocidal activity against Streptococcus pneumoniae.
Critical care pcd franchise Vistica Life’s Tigecycline offers a broad spectrum of activity against many gram-positive, gram-negative and anaerobic organisms including multidrug-resistant strains of gram-positive organisms, such as MRSA and MRSE, penicillin-resistant Streptococcus pneumoniae, and VRE species.
For pregnant women or children younger than 8 years tigecycline is not recommended.
Tigecycline is not recommended in the treatment of diabetic foot infections. It is not indicated for the treatment of hospital-acquired or ventilator-associated pneumonia. It should be used only to treat infections that are proven or strongly suspected to be caused by susceptible bacteria. As empirical therapy for polymicrobial infections, tigecycline is considered as most useful particularly in cases in which deep tissue penetration is needed or in which multidrug-resistance pathogens are suspected.
Critical care pcd franchise company Vistica Life’s Tigecycline is available in powder form to be mixed with fluid for injection and should be injected into a vein. It should be normally infused slowly intravenously over a period of 30 to 60 minutes once every 12 hour. Type of infection and the body’s response are the deciding factors for the length of treatment.
One may receive critical care pcd franchise company Vistica’s tigecycline injection in a hospital or use the medication at home. If using tigecycline injection at home, one’s healthcare provider should show how to infuse the medication. Immediately consult the healthcare provider if any complication arises after the infusion of the drug.
One should start to feel better during the first few days of treatment with tigecycline injection. If the symptoms do not improve or get wors
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Cutthroat & Cavalier
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Critical care pcd franchise company Vistica Life’s Tigecycline must be used only when prescribed by the doctor. You must inform the doctor if you are allergic to tigecycline or any tetracycline. You should inform the doctor if you are on any other medication. If you are having any liver disease, inform the doctor before taking the medicine. The doctors must be intimated if the patient is in pregnancy or breast feeding condition.
Though tigecycline offers a great tissue penetration, it has very low plasma concentrations. Therefore, it is not considered an ideal agent for treatment of bacteremia or other endovascular infections.
All the information mentioned above have been taken from different references. It is suggested to get confirmation before following any of the facts from the concerned authority legally.
